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2fif
From Proteopedia
(Difference between revisions)
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==Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin== | ==Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin== | ||
| - | <StructureSection load='2fif' size='340' side='right' caption='[[2fif]], [[Resolution|resolution]] 2.49Å' scene=''> | + | <StructureSection load='2fif' size='340' side='right'caption='[[2fif]], [[Resolution|resolution]] 2.49Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2fif]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2fif]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin] and [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FIF FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RABGEF1, RABEX5 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RABGEF1, RABEX5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fif OCA], [https://pdbe.org/2fif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fif RCSB], [https://www.ebi.ac.uk/pdbsum/2fif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fif ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RABX5_BOVIN RABX5_BOVIN]] Rab effector protein acting as linker between gamma-adaptin and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.<ref>PMID:9323142</ref> <ref>PMID:16462746</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Rab5 GDP/GTP exchange factor|Rab5 GDP/GTP exchange factor]] | *[[Rab5 GDP/GTP exchange factor|Rab5 GDP/GTP exchange factor]] | ||
| - | *[[ | + | *[[3D structures of ubiquitin|3D structures of ubiquitin]] |
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Bovin]] | [[Category: Bovin]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hurley, J H]] | [[Category: Hurley, J H]] | ||
[[Category: Lee, S]] | [[Category: Lee, S]] | ||
Revision as of 15:27, 3 March 2021
Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin
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