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2fo1

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==Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA==
==Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA==
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<StructureSection load='2fo1' size='340' side='right' caption='[[2fo1]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
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<StructureSection load='2fo1' size='340' side='right'caption='[[2fo1]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2fo1]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2FO1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2fo1]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FO1 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LAG-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL]), sel-8, lag-3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL]), lin-12 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LAG-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL]), sel-8, lag-3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL]), lin-12 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fo1 OCA], [http://pdbe.org/2fo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2fo1 RCSB], [http://www.ebi.ac.uk/pdbsum/2fo1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2fo1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fo1 OCA], [https://pdbe.org/2fo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fo1 RCSB], [https://www.ebi.ac.uk/pdbsum/2fo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fo1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/LAG3_CAEEL LAG3_CAEEL]] Glp-1 and lin-12 promote signalling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator. [[http://www.uniprot.org/uniprot/LIN12_CAEEL LIN12_CAEEL]] Involved in several cell fate decisions that require cell-cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.<ref>PMID:3419531</ref> <ref>PMID:3000611</ref>
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[[https://www.uniprot.org/uniprot/LAG3_CAEEL LAG3_CAEEL]] Glp-1 and lin-12 promote signalling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator. [[https://www.uniprot.org/uniprot/LIN12_CAEEL LIN12_CAEEL]] Involved in several cell fate decisions that require cell-cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10.<ref>PMID:3419531</ref> <ref>PMID:3000611</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Caeel]]
[[Category: Caeel]]
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[[Category: Large Structures]]
[[Category: Kovall, R A]]
[[Category: Kovall, R A]]
[[Category: Wilson, J J]]
[[Category: Wilson, J J]]

Revision as of 15:30, 3 March 2021

Crystal Structure of the CSL-Notch-Mastermind ternary complex bound to DNA

PDB ID 2fo1

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