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2etw

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==Principles of protein-DNA recognition revealed in the structural analysis of Ndt80-MSE DNA complexes==
==Principles of protein-DNA recognition revealed in the structural analysis of Ndt80-MSE DNA complexes==
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<StructureSection load='2etw' size='340' side='right' caption='[[2etw]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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<StructureSection load='2etw' size='340' side='right'caption='[[2etw]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2etw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ETW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ETW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2etw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ETW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ETW FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mnn|1mnn]], [[1mn4|1mn4]], [[1m6u|1m6u]], [[1m7u|1m7u]], [[2euv|2euv]], [[2euw|2euw]], [[2eux|2eux]], [[2euz|2euz]], [[2evf|2evf]], [[2evg|2evg]], [[2evh|2evh]], [[2ehi|2ehi]], [[2ehj|2ehj]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mnn|1mnn]], [[1mn4|1mn4]], [[1m6u|1m6u]], [[1m7u|1m7u]], [[2euv|2euv]], [[2euw|2euw]], [[2eux|2eux]], [[2euz|2euz]], [[2evf|2evf]], [[2evg|2evg]], [[2evh|2evh]], [[2ehi|2ehi]], [[2ehj|2ehj]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NDT80 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NDT80 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2etw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2etw OCA], [http://pdbe.org/2etw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2etw RCSB], [http://www.ebi.ac.uk/pdbsum/2etw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2etw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2etw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2etw OCA], [https://pdbe.org/2etw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2etw RCSB], [https://www.ebi.ac.uk/pdbsum/2etw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2etw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NDT80_YEAST NDT80_YEAST]] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.<ref>PMID:8524222</ref> <ref>PMID:9660952</ref> <ref>PMID:9742092</ref> <ref>PMID:12832469</ref>
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[[https://www.uniprot.org/uniprot/NDT80_YEAST NDT80_YEAST]] Transcription factor required for successful completion of meiosis and spore formation. Gets activated after completion of meiotic recombination at the end of prophase I. Recognizes and binds to the middle sporulation element (MSE) 5'-C[AG]CAAA[AT]-3' in the promoter region of stage-specific genes that are required for progression through meiosis and sporulation. Competes for binding to MSE with the transcriptional repressor SUM1, which represses middle sporulation-specific genes during mitosis and early sporulation.<ref>PMID:8524222</ref> <ref>PMID:9660952</ref> <ref>PMID:9742092</ref> <ref>PMID:12832469</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Atcc 18824]]
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[[Category: Large Structures]]
[[Category: Glover, J N]]
[[Category: Glover, J N]]
[[Category: Lamoureux, J S]]
[[Category: Lamoureux, J S]]

Revision as of 12:29, 10 February 2021

Principles of protein-DNA recognition revealed in the structural analysis of Ndt80-MSE DNA complexes

PDB ID 2etw

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