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Hirudin
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The <scene name='41/417483/Cv/ | + | The <scene name='41/417483/Cv/4'>N-terminal tripeptide of hirudin (green) binds to the heavy chain of thrombin (magenta) and interacts with two of its active site residues: Ser195 and His57</scene><ref>PMID:1920434</ref>. |
</StructureSection> | </StructureSection> | ||
== 3D Structures of Hirudin == | == 3D Structures of Hirudin == | ||
Revision as of 12:39, 16 May 2019
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3D Structures of Hirudin
Updated on 16-May-2019
References
- ↑ Fenton JW 2nd, Ofosu FA, Brezniak DV, Hassouna HI. Thrombin and antithrombotics. Semin Thromb Hemost. 1998;24(2):87-91. PMID:9579630 doi:http://dx.doi.org/10.1055/s-2007-995828
- ↑ Stamenova PK, Marchetti T, Simeonov I. Efficacy and safety of topical hirudin (Hirudex): a double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2001 Mar-Apr;5(2):37-42. PMID:11863317
- ↑ Johnson PH. Hirudin: clinical potential of a thrombin inhibitor. Annu Rev Med. 1994;45:165-77. PMID:8198374 doi:http://dx.doi.org/10.1146/annurev.med.45.1.165
- ↑ Rydel TJ, Tulinsky A, Bode W, Huber R. Refined structure of the hirudin-thrombin complex. J Mol Biol. 1991 Sep 20;221(2):583-601. PMID:1920434
