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5yxd

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'''Unreleased structure'''
 
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The entry 5yxd is ON HOLD until Paper Publication
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==A ligand F binding to FXR==
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<StructureSection load='5yxd' size='340' side='right'caption='[[5yxd]], [[Resolution|resolution]] 2.98&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5yxd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YXD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YXD FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=93R:ethyl+methyl+4-(2,3-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate'>93R</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yxd OCA], [http://pdbe.org/5yxd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yxd RCSB], [http://www.ebi.ac.uk/pdbsum/5yxd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yxd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Yi, L]]
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[[Category: Yong, L]]
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[[Category: Complex]]
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[[Category: Nuclear protein]]

Revision as of 11:51, 13 March 2019

A ligand F binding to FXR

PDB ID 5yxd

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OCA

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