2jfb

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[[Image:2jfb.jpg|left|200px]]
[[Image:2jfb.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2jfb |SIZE=350|CAPTION= <scene name='initialview01'>2jfb</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2jfb", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mpd+Binding+Site+For+Chain+K'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2jfb| PDB=2jfb | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jfb OCA], [http://www.ebi.ac.uk/pdbsum/2jfb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jfb RCSB]</span>
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}}
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'''3D STRUCTURE OF LUMAZINE SYNTHASE FROM CANDIDA ALBICANS'''
'''3D STRUCTURE OF LUMAZINE SYNTHASE FROM CANDIDA ALBICANS'''
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[[Category: Ladenstein, R.]]
[[Category: Ladenstein, R.]]
[[Category: Morgunova, E.]]
[[Category: Morgunova, E.]]
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[[Category: candida albican]]
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[[Category: Candida albican]]
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[[Category: lumazine synthase]]
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[[Category: Lumazine synthase]]
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[[Category: riboflavin biosynthesis]]
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[[Category: Riboflavin biosynthesis]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:49:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:57:25 2008''
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Revision as of 05:49, 4 May 2008

Image:2jfb.jpg

Template:STRUCTURE 2jfb

3D STRUCTURE OF LUMAZINE SYNTHASE FROM CANDIDA ALBICANS


Overview

Lumazine synthase is an enzyme involved in riboflavin biosynthesis in many plants and microorganisms, including numerous human pathogens. The fact that the enzymes of the riboflavin biosynthesis pathway are not present in the human or animal host makes them potential targets for anti-infective agents. The crystal structure of lumazine synthase from Candida albicans was solved by molecular replacement and refined at 2.5-Angstrom resolution. The results of crystallographic investigations and sedimentation equilibrium experiments clearly indicated the presence of pentameric assemblies of the enzyme either in crystals or in solution. Isothermal titration calorimetry measurements of the binding reactions of four different inhibitors revealed high affinity for all four compounds with binding constants in the micromolar range. Structural comparison with previously determined structures of the enzyme.ligand complexes of other orthologue allowed modeling of the binding of four different inhibitors into the active site of lumazine synthase from Candida albicans.

About this Structure

2JFB is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.

Reference

Lumazine synthase from Candida albicans as an anti-fungal target enzyme: structural and biochemical basis for drug design., Morgunova E, Saller S, Haase I, Cushman M, Bacher A, Fischer M, Ladenstein R, J Biol Chem. 2007 Jun 8;282(23):17231-41. Epub 2007 Apr 18. PMID:17446177 Page seeded by OCA on Sun May 4 08:49:28 2008

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