2jhb
From Proteopedia
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'''CORE BINDING FACTOR BETA''' | '''CORE BINDING FACTOR BETA''' | ||
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[[Category: Peng, J.]] | [[Category: Peng, J.]] | ||
[[Category: Speck, N A.]] | [[Category: Speck, N A.]] | ||
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Revision as of 05:55, 4 May 2008
CORE BINDING FACTOR BETA
Overview
The core binding factor beta subunit (CBF beta) is the non-DNA binding subunit of the core-binding factors, transcription factors essential for multiple developmental processes including hematopoiesis and bone development. Chromosomal translocations involving the human CBFB gene are associated with a large percentage of human leukemias. The N-terminal 141 amino acids of CBF beta contains the heterodimerization domain for the DNA-binding CBF alpha subunits, and is sufficient for CBF beta function in vivo. Here we present the high-resolution solution structure of the CBF beta heterodimerization domain. It is a novel alpha/beta structure consisting of two three-stranded beta-sheets packed on one another in a sandwich arrangement, with four peripheral alpha-helices. The CBF alpha binding site on CBF beta has been mapped by chemical shift perturbation analysis.
About this Structure
2JHB is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Solution structure of core binding factor beta and map of the CBF alpha binding site., Huang X, Peng JW, Speck NA, Bushweller JH, Nat Struct Biol. 1999 Jul;6(7):624-7. PMID:10404216 Page seeded by OCA on Sun May 4 08:55:14 2008
