2jm6

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[[Image:2jm6.gif|left|200px]]
[[Image:2jm6.gif|left|200px]]
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{{Structure
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|PDB= 2jm6 |SIZE=350|CAPTION= <scene name='initialview01'>2jm6</scene>
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The line below this paragraph, containing "STRUCTURE_2jm6", creates the "Structure Box" on the page.
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|SITE=
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|GENE= Pmaip1, Noxa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), Mcl1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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{{STRUCTURE_2jm6| PDB=2jm6 | SCENE= }}
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|RELATEDENTRY=[[1wsx|1WSX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jm6 OCA], [http://www.ebi.ac.uk/pdbsum/2jm6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jm6 RCSB]</span>
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'''Solution structure of MCL-1 complexed with NOXAB'''
'''Solution structure of MCL-1 complexed with NOXAB'''
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[[Category: Lee, E F.]]
[[Category: Lee, E F.]]
[[Category: Smith, B J.]]
[[Category: Smith, B J.]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: bcl-2]]
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[[Category: Bcl-2]]
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[[Category: bh3-only]]
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[[Category: Bh3-only]]
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[[Category: helical bundle]]
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[[Category: Helical bundle]]
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[[Category: mcl-1]]
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[[Category: Mcl-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:01:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:59:08 2008''
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Revision as of 06:01, 4 May 2008

Image:2jm6.gif

Template:STRUCTURE 2jm6

Solution structure of MCL-1 complexed with NOXAB


Overview

Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.

About this Structure

2JM6 is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural insights into the degradation of Mcl-1 induced by BH3 domains., Czabotar PE, Lee EF, van Delft MF, Day CL, Smith BJ, Huang DC, Fairlie WD, Hinds MG, Colman PM, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6217-22. Epub 2007 Mar 27. PMID:17389404 Page seeded by OCA on Sun May 4 09:01:16 2008

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