2g0l
From Proteopedia
(Difference between revisions)
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==Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone== | ==Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone== | ||
| - | <StructureSection load='2g0l' size='340' side='right' caption='[[2g0l]], [[NMR_Ensembles_of_Models | 58 NMR models]]' scene=''> | + | <StructureSection load='2g0l' size='340' side='right'caption='[[2g0l]], [[NMR_Ensembles_of_Models | 58 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2g0l]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2g0l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/'streptomyces_carzinostaticus' 'streptomyces carzinostaticus']. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G0L FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLN:2-PHENYL-4H-CHROMEN-4-ONE'>FLN</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLN:2-PHENYL-4H-CHROMEN-4-ONE'>FLN</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j5h|1j5h]], [[1j5i|1j5i]], [[2g0k|2g0k]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1j5h|1j5h]], [[1j5i|1j5i]], [[2g0k|2g0k]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ncsA ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ncsA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1897 'Streptomyces carzinostaticus'])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g0l OCA], [https://pdbe.org/2g0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g0l RCSB], [https://www.ebi.ac.uk/pdbsum/2g0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g0l ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Streptomyces carzinostaticus]] | [[Category: Streptomyces carzinostaticus]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Caddick, S]] | [[Category: Caddick, S]] | ||
[[Category: Muskett, F W]] | [[Category: Muskett, F W]] | ||
Revision as of 15:37, 3 March 2021
Solution Structure of Neocarzinostatin Apo-Protein with bound Flavone
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