2jpp

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[[Image:2jpp.gif|left|200px]]
[[Image:2jpp.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2jpp |SIZE=350|CAPTION= <scene name='initialview01'>2jpp</scene>
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The line below this paragraph, containing "STRUCTURE_2jpp", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= rsmE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=294 Pseudomonas fluorescens])
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-->
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|DOMAIN=
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{{STRUCTURE_2jpp| PDB=2jpp | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jpp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jpp OCA], [http://www.ebi.ac.uk/pdbsum/2jpp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jpp RCSB]</span>
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}}
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'''Structural basis of RsmA/CsrA RNA recognition: Structure of RsmE bound to the Shine-Dalgarno sequence of hcnA mRNA'''
'''Structural basis of RsmA/CsrA RNA recognition: Structure of RsmE bound to the Shine-Dalgarno sequence of hcnA mRNA'''
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[[Category: Oberstrass, F C.]]
[[Category: Oberstrass, F C.]]
[[Category: Schubert, M.]]
[[Category: Schubert, M.]]
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[[Category: csra]]
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[[Category: Csra]]
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[[Category: protein/rna]]
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[[Category: Protein/rna]]
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[[Category: rna recognition]]
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[[Category: Rna recognition]]
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[[Category: rsma]]
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[[Category: Rsma]]
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[[Category: shine-dalgarno]]
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[[Category: Shine-dalgarno]]
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[[Category: translation/rna complex]]
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[[Category: Translation/rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:09:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:00:31 2008''
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Revision as of 06:09, 4 May 2008

Image:2jpp.gif

Template:STRUCTURE 2jpp

Structural basis of RsmA/CsrA RNA recognition: Structure of RsmE bound to the Shine-Dalgarno sequence of hcnA mRNA


Overview

Proteins of the RsmA/CsrA family are global translational regulators in many bacterial species. We have determined the solution structure of a complex formed between the RsmE protein, a member of this family from Pseudomonas fluorescens, and a target RNA encompassing the ribosome-binding site of the hcnA gene. The RsmE homodimer with its two RNA-binding sites makes optimal contact with an 5'-A/UCANGGANGU/A-3' sequence in the mRNA. When tightly gripped by RsmE, the ANGGAN core folds into a loop, favoring the formation of a 3-base-pair stem by flanking nucleotides. We validated these findings by in vivo and in vitro mutational analyses. The structure of the complex explains well how, by sequestering the Shine-Dalgarno sequence, the RsmA/CsrA proteins repress translation.

About this Structure

2JPP is a Single protein structure of sequence from Pseudomonas fluorescens. Full crystallographic information is available from OCA.

Reference

Molecular basis of messenger RNA recognition by the specific bacterial repressing clamp RsmA/CsrA., Schubert M, Lapouge K, Duss O, Oberstrass FC, Jelesarov I, Haas D, Allain FH, Nat Struct Mol Biol. 2007 Sep;14(9):807-13. Epub 2007 Aug 19. PMID:17704818 Page seeded by OCA on Sun May 4 09:09:37 2008

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