5xv6
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of ATG101-ATG13HORMA== | |
| - | + | <StructureSection load='5xv6' size='340' side='right' caption='[[5xv6]], [[Resolution|resolution]] 2.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5xv6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XV6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xv6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xv6 OCA], [http://pdbe.org/5xv6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xv6 RCSB], [http://www.ebi.ac.uk/pdbsum/5xv6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xv6 ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: Kim, B | + | == Function == |
| - | [[Category: Song, H | + | [[http://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN]] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref> [[http://www.uniprot.org/uniprot/ATGA1_HUMAN ATGA1_HUMAN]] Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.<ref>PMID:19287211</ref> <ref>PMID:19597335</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Kim, B W]] | ||
| + | [[Category: Song, H K]] | ||
| + | [[Category: Atg101]] | ||
| + | [[Category: Atg13]] | ||
| + | [[Category: Autophagy]] | ||
| + | [[Category: Horma]] | ||
| + | [[Category: Protein binding]] | ||
Revision as of 07:07, 4 July 2018
Crystal structure of ATG101-ATG13HORMA
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Categories: Kim, B W | Song, H K | Atg101 | Atg13 | Autophagy | Horma | Protein binding
