5z8y
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a synaptic protein complex== | |
| + | <StructureSection load='5z8y' size='340' side='right' caption='[[5z8y]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5z8y]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z8Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z8Y FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z8y OCA], [http://pdbe.org/5z8y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z8y RCSB], [http://www.ebi.ac.uk/pdbsum/5z8y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z8y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/NRX1B_HUMAN NRX1B_HUMAN]] Pitt-Hopkins-like syndrome;Autism;Schizophrenia. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LRRT2_HUMAN LRRT2_HUMAN]] Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity). [[http://www.uniprot.org/uniprot/NRX1B_HUMAN NRX1B_HUMAN]] Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) function as postsynaptic organizers that induce excitatory synapses. Neurexins (Nrxns) and heparan sulfate proteoglycans have been identified as presynaptic ligands for LRRTMs. Specifically, LRRTM1 and LRRTM2 bind to the Nrxn splice variant lacking an insert at the splice site 4 (S4). Here, we report the crystal structure of the Nrxn1beta-LRRTM2 complex at 3.4 A resolution. The Nrxn1beta-LRRTM2 interface involves Ca(2+)-mediated interactions and overlaps with the Nrxn-neuroligin interface. Together with structure-based mutational analyses at the molecular and cellular levels, the present structural analysis unveils the mechanism of selective binding between Nrxn and LRRTM1/2 and its modulation by the S4 insertion of Nrxn. | ||
| - | + | Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.,Yamagata A, Goto-Ito S, Sato Y, Shiroshima T, Maeda A, Watanabe M, Saitoh T, Maenaka K, Terada T, Yoshida T, Uemura T, Fukai S Nat Commun. 2018 Sep 27;9(1):3964. doi: 10.1038/s41467-018-06333-8. PMID:30262834<ref>PMID:30262834</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5z8y" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fukai, S]] | ||
| + | [[Category: Yamagata, A]] | ||
| + | [[Category: Cell adhesion]] | ||
| + | [[Category: Leucine-rich repeat]] | ||
| + | [[Category: Synapse]] | ||
| + | [[Category: Synaptic organizer]] | ||
Revision as of 08:00, 10 October 2018
Crystal structure of a synaptic protein complex
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