5zyu
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Crytal struture of humanMGME1 with single strand DNA2== |
| - | + | <StructureSection load='5zyu' size='340' side='right' caption='[[5zyu]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5zyu]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZYU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZYU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zyu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zyu OCA], [http://pdbe.org/5zyu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zyu RCSB], [http://www.ebi.ac.uk/pdbsum/5zyu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zyu ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/MGME1_HUMAN MGME1_HUMAN]] Progressive external ophthalmoplegia - myopathy - emaciation. The disease may be caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MGME1_HUMAN MGME1_HUMAN]] Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.[HAMAP-Rule:MF_03030]<ref>PMID:23313956</ref> <ref>PMID:23358826</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gan, J]] | ||
| + | [[Category: Yang, C]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Dna binding protein-dna complex]] | ||
| + | [[Category: Dna complex]] | ||
| + | [[Category: Dna exonuclease]] | ||
| + | [[Category: Huamnmgme1]] | ||
Revision as of 19:42, 19 September 2018
Crytal struture of humanMGME1 with single strand DNA2
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