2jso
From Proteopedia
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'''Antimicrobial resistance protein''' | '''Antimicrobial resistance protein''' | ||
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[[Category: Fu, W.]] | [[Category: Fu, W.]] | ||
[[Category: Jin, C.]] | [[Category: Jin, C.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:15:35 2008'' | |
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Revision as of 06:15, 4 May 2008
Antimicrobial resistance protein
Overview
PmrA/PmrB and PhoP/PhoQ are a pair of two-component systems (TCSs) that allow the Gram-negative bacteria to survive the cationic antimicrobial peptide polymyxin B. The two TCSs are linked by the polymyxin resistance protein, PmrD. The PhoP-activated PmrD protects the phosphorylated response regulator PmrA from dephosphorylation, and promotes the transcription of PmrA-activated genes responsible for polymyxin resistance. PmrD is the first protein identified to mediate the connectivity between two TCSs by protecting the phosphorylated response regulator of the downstream TCS. PmrD shows no homology to proteins with known structures. We present here the solution structure of PmrD from Escherichia coli, the first three-dimensional structure of the PmrD family. Our study provides the structural basis of the novel interacting mechanism of bacterial two-component signal-transduction systems.
About this Structure
2JSO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
First structure of the polymyxin resistance proteins., Fu W, Yang F, Kang X, Zhang X, Li Y, Xia B, Jin C, Biochem Biophys Res Commun. 2007 Oct 5;361(4):1033-7. Epub 2007 Aug 2. PMID:17686460 Page seeded by OCA on Sun May 4 09:15:35 2008
