6gw3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6gw3" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6gw3 is ON HOLD
+
==Structure of TKS from Cannabis sativa in complex with CoA==
-
 
+
<StructureSection load='6gw3' size='340' side='right'caption='[[6gw3]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6gw3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GW3 FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr>
 +
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3,5,7-trioxododecanoyl-CoA_synthase 3,5,7-trioxododecanoyl-CoA synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.206 2.3.1.206] </span></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gw3 OCA], [http://pdbe.org/6gw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gw3 RCSB], [http://www.ebi.ac.uk/pdbsum/6gw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gw3 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/OLIS_CANSA OLIS_CANSA]] Polyketide synthase responsible for olivetol biosynthesis. Catalyzes the first step in the cannabinoids biosynthetic pathway. The preferred substrate is hexanoyl-CoA, but accepts also CoA esters with C4 to C8 aliphatic side chains. When using malonyl-CoA and hexanoyl-CoA as substrates, produces undetermined compounds distinct form olivetol or olivetolic acid (PubMed:19581347) that could be hexanoyl triacetic acid lactone (HTAL) (PubMed:18323613) and pentyl diacetic acid lactone (PDAL) (PubMed:22802619). Produces olivetolic acid when acting in concert with olivetolic acid cyclase (OAC).<ref>PMID:18323613</ref> <ref>PMID:19454282</ref> <ref>PMID:19581347</ref> <ref>PMID:22802619</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: 3,5,7-trioxododecanoyl-CoA synthase]]
 +
[[Category: Large Structures]]
 +
[[Category: Karuppiah, V]]
 +
[[Category: Leys, D]]
 +
[[Category: 7-trioxododecanoyl-coa synthase]]
 +
[[Category: Ligase]]
 +
[[Category: Pks type iii]]
 +
[[Category: Polyketide synthase]]

Revision as of 05:13, 10 October 2019

Structure of TKS from Cannabis sativa in complex with CoA

PDB ID 6gw3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6gw3"
Personal tools