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2jwq

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[[Image:2jwq.jpg|left|200px]]
[[Image:2jwq.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2jwq |SIZE=350|CAPTION= <scene name='initialview01'>2jwq</scene>
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The line below this paragraph, containing "STRUCTURE_2jwq", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Mm0+Binding+Site+For+Residue+B+29'>AC1</scene> and <scene name='pdbsite=AC2:Mm0+Binding+Site+For+Residue+B+30'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MM0:N,N&#39;-(DIBENZO[B,J][1,7]PHENANTHROLINE-2,10-DIYLDIMETHANEDIYL)DIPROPAN-1-AMINE'>MM0</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2jwq| PDB=2jwq | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwq OCA], [http://www.ebi.ac.uk/pdbsum/2jwq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jwq RCSB]</span>
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}}
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'''G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study'''
'''G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study'''
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==About this Structure==
==About this Structure==
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2JWQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].
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2JWQ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWQ OCA].
==Reference==
==Reference==
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[[Category: Saettel, N.]]
[[Category: Saettel, N.]]
[[Category: Teulade-Fichou, M.]]
[[Category: Teulade-Fichou, M.]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: g-quadruplex]]
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[[Category: G-quadruplex]]
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[[Category: quinacridine]]
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[[Category: Quinacridine]]
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[[Category: telomerase inhibitor]]
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[[Category: Telomerase inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:21:40 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:02:18 2008''
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Revision as of 06:21, 4 May 2008

Image:2jwq.jpg

Template:STRUCTURE 2jwq

G-quadruplex recognition by quinacridines: a SAR, NMR and Biological study


Overview

The synthesis of a novel group of quinacridine-based ligands (MMQs) is described along with an evaluation of their G-quadruplex binding properties. A set of biophysical assays was applied to characterize their interaction with DNA quadruplexes: FRET-melting experiments and equilibrium microdialysis were used to evaluate their quadruplex affinity and their ability to discriminate quadruplexes across a broad panel of DNA structures. All data collected support the proposed model of interaction of these compounds with G-quadruplexes, which is furthermore confirmed by a solution structure determined by 2D NMR experiments. Finally, the activity of the MMQ series against tumor cell growth is reported, and the data support the potential of quadruplex-interactive compounds for use in anticancer approaches.

About this Structure

2JWQ is a Single protein structure. Full crystallographic information is available from OCA.

Reference

G-Quadruplex Recognition by Quinacridines: a SAR, NMR, and Biological Study., Hounsou C, Guittat L, Monchaud D, Jourdan M, Saettel N, Mergny JL, Teulade-Fichou MP, ChemMedChem. 2007 May;2(5):655-66. PMID:17385760 Page seeded by OCA on Sun May 4 09:21:40 2008

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