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6b4k

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Current revision (14:32, 4 October 2023) (edit) (undo)
 
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==Crystal structure of human DDX19B(AMPPNP)==
==Crystal structure of human DDX19B(AMPPNP)==
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<StructureSection load='6b4k' size='340' side='right' caption='[[6b4k]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='6b4k' size='340' side='right'caption='[[6b4k]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6b4k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B4K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B4K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6b4k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B4K FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDX19B, DBP5, DDX19, TDBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_helicase RNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.13 3.6.4.13] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b4k OCA], [https://pdbe.org/6b4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b4k RCSB], [https://www.ebi.ac.uk/pdbsum/6b4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b4k ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b4k OCA], [http://pdbe.org/6b4k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b4k RCSB], [http://www.ebi.ac.uk/pdbsum/6b4k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b4k ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN]] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
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[https://www.uniprot.org/uniprot/DD19B_HUMAN DD19B_HUMAN] ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6b4k" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6b4k" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Helicase 3D structures|Helicase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: RNA helicase]]
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[[Category: Large Structures]]
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[[Category: Cai, S W]]
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[[Category: Cai SW]]
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[[Category: Correia, A R]]
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[[Category: Correia AR]]
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[[Category: Hoelz, A]]
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[[Category: Hoelz A]]
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[[Category: Huber, F M]]
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[[Category: Huber FM]]
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[[Category: Jette, C A]]
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[[Category: Jette CA]]
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[[Category: Lin, D H]]
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[[Category: Lin DH]]
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[[Category: Complex]]
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[[Category: Dead-box helicase]]
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[[Category: Mrna export]]
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[[Category: Nuclear pore complex]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of human DDX19B(AMPPNP)

PDB ID 6b4k

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