2hi1

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==The structure of a putative 4-hydroxythreonine-4-phosphate dehydrogenase from Salmonella typhimurium.==
==The structure of a putative 4-hydroxythreonine-4-phosphate dehydrogenase from Salmonella typhimurium.==
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<StructureSection load='2hi1' size='340' side='right' caption='[[2hi1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='2hi1' size='340' side='right'caption='[[2hi1]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2hi1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HI1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2hi1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HI1 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pdxA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pdxA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxythreonine-4-phosphate_dehydrogenase 4-hydroxythreonine-4-phosphate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.262 1.1.1.262] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/4-hydroxythreonine-4-phosphate_dehydrogenase 4-hydroxythreonine-4-phosphate dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.262 1.1.1.262] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi1 OCA], [http://pdbe.org/2hi1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2hi1 RCSB], [http://www.ebi.ac.uk/pdbsum/2hi1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi1 ProSAT], [http://www.topsan.org/Proteins/MCSG/2hi1 TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hi1 OCA], [https://pdbe.org/2hi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hi1 RCSB], [https://www.ebi.ac.uk/pdbsum/2hi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hi1 ProSAT], [https://www.topsan.org/Proteins/MCSG/2hi1 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDXA2_SALTY PDXA2_SALTY]] Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity).[HAMAP-Rule:MF_00536]
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[[https://www.uniprot.org/uniprot/PDXA2_SALTY PDXA2_SALTY]] Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity).[HAMAP-Rule:MF_00536]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: 4-hydroxythreonine-4-phosphate dehydrogenase]]
[[Category: 4-hydroxythreonine-4-phosphate dehydrogenase]]
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[[Category: Large Structures]]
[[Category: Salty]]
[[Category: Salty]]
[[Category: Cuff, M E]]
[[Category: Cuff, M E]]

Revision as of 07:40, 17 March 2021

The structure of a putative 4-hydroxythreonine-4-phosphate dehydrogenase from Salmonella typhimurium.

PDB ID 2hi1

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