2mcm

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[[Image:2mcm.jpg|left|200px]]
[[Image:2mcm.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2mcm", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>
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{{STRUCTURE_2mcm| PDB=2mcm | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcm OCA], [http://www.ebi.ac.uk/pdbsum/2mcm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2mcm RCSB]</span>
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'''MACROMOMYCIN'''
'''MACROMOMYCIN'''
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[[Category: Streptomyces macromomyceticus]]
[[Category: Streptomyces macromomyceticus]]
[[Category: Vanroey, P.]]
[[Category: Vanroey, P.]]
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[[Category: apoprotein]]
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[[Category: Apoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:32:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:03:50 2008''
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Revision as of 06:32, 4 May 2008

Image:2mcm.jpg

Template:STRUCTURE 2mcm

MACROMOMYCIN


Overview

The crystal structure of macromomycin, the apoprotein of the antitumor antibiotic auromomycin, has been determined and refined at 1.6-A resolution. The overall structure is composed of a flattened seven-stranded antiparallel beta-barrel and two antiparallel beta-sheet ribbons. The barrel and the ribbons define a deep cleft that is the chromophore binding site. The cleft is very accessible and in this structure is occupied by two 2-methyl-2,4-pentanediol and two water molecules. The overall shape of the binding site is similar to that of the analogue actinoxanthin. Highly specific side chains that are not conserved between different analogues extend into the binding site and may be important to the chromophore binding specificity.

About this Structure

2MCM is a Single protein structure of sequence from Streptomyces macromomyceticus. Full crystallographic information is available from OCA.

Reference

Crystal structure analysis of auromomycin apoprotein (macromomycin) shows importance of protein side chains to chromophore binding selectivity., Van Roey P, Beerman TA, Proc Natl Acad Sci U S A. 1989 Sep;86(17):6587-91. PMID:2771945 Page seeded by OCA on Sun May 4 09:32:07 2008

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