2nll

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[[Image:2nll.gif|left|200px]]
[[Image:2nll.gif|left|200px]]
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{{Structure
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|PDB= 2nll |SIZE=350|CAPTION= <scene name='initialview01'>2nll</scene>, resolution 1.900&Aring;
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The line below this paragraph, containing "STRUCTURE_2nll", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=5IU:5-IODO-2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>5IU</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_2nll| PDB=2nll | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nll OCA], [http://www.ebi.ac.uk/pdbsum/2nll PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nll RCSB]</span>
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'''RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA'''
'''RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA'''
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[[Category: Rastinejad, F.]]
[[Category: Rastinejad, F.]]
[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
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[[Category: alternative splicing]]
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[[Category: Alternative splicing]]
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[[Category: complex (transcription regulation/dna)]]
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[[Category: Dna-binding]]
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[[Category: dna-binding]]
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[[Category: Multigene family]]
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[[Category: multigene family]]
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[[Category: Nuclear protein]]
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[[Category: nuclear protein]]
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[[Category: Receptor]]
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[[Category: receptor]]
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[[Category: Zinc- finger]]
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[[Category: zinc- finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:36:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:04:55 2008''
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Revision as of 06:36, 4 May 2008

Image:2nll.gif

Template:STRUCTURE 2nll

RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA


Overview

Nuclear receptor heterodimers recognize response elements composed of two direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs. The 1.9 A crystal structure of the complex formed by the DNA-binding domains of the 9-cis retinoic acid receptor and thyroid hormone receptor bound to a thyroid-response element shows that the subunits interact through a DNA-supported interface involving the carboxy-terminal extension of the DNA-binding domain of the thyroid hormone receptor. The stereochemistry suggests a mechanism by which heterodimers recognize the inter-half-site spacing between direct repeats.

About this Structure

2NLL is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural determinants of nuclear receptor assembly on DNA direct repeats., Rastinejad F, Perlmann T, Evans RM, Sigler PB, Nature. 1995 May 18;375(6528):203-11. PMID:7746322 Page seeded by OCA on Sun May 4 09:36:50 2008

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