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6gwj

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m (Protected "6gwj" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6gwj is ON HOLD
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==protein complex==
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<StructureSection load='6gwj' size='340' side='right'caption='[[6gwj]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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Authors: Missoury, S., Ligier, D., Durand, D., Collinet, B., Tilbeurgh, V.H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6gwj]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GWJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GWJ FirstGlance]. <br>
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Description: protein complex
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N(6)-L-threonylcarbamoyladenine_synthase N(6)-L-threonylcarbamoyladenine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.234 2.3.1.234] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gwj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gwj OCA], [http://pdbe.org/6gwj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gwj RCSB], [http://www.ebi.ac.uk/pdbsum/6gwj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gwj ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/LAGE3_HUMAN LAGE3_HUMAN]] Galloway-Mowat syndrome. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/OSGEP_HUMAN OSGEP_HUMAN]] Galloway-Mowat syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/LAGE3_HUMAN LAGE3_HUMAN]] Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.<ref>PMID:22912744</ref> <ref>PMID:27903914</ref> [[http://www.uniprot.org/uniprot/OSGEP_HUMAN OSGEP_HUMAN]] Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.[HAMAP-Rule:MF_03180]<ref>PMID:28272532</ref> <ref>PMID:28805828</ref> <ref>PMID:22912744</ref> <ref>PMID:27903914</ref> [[http://www.uniprot.org/uniprot/GON7_HUMAN GON7_HUMAN]] Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.[UniProtKB:P46984]<ref>PMID:27903914</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Collinet, B]]
[[Category: Durand, D]]
[[Category: Durand, D]]
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[[Category: Ligier, D]]
[[Category: Missoury, S]]
[[Category: Missoury, S]]
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[[Category: Collinet, B]]
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[[Category: Tilbeurgh, V H]]
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[[Category: Ligier, D]]
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[[Category: Rna binding protein]]
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[[Category: Tilbeurgh, V.H]]
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[[Category: T6a modification]]
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[[Category: Trna]]

Revision as of 05:47, 3 July 2019

protein complex

PDB ID 6gwj

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