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2i7n

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==Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA==
==Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA==
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<StructureSection load='2i7n' size='340' side='right' caption='[[2i7n]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='2i7n' size='340' side='right'caption='[[2i7n]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I7N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2i7n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I7N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2i7p|2i7p]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2i7p|2i7p]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PANK1, PANK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pantothenate_kinase Pantothenate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.33 2.7.1.33] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [http://pdbe.org/2i7n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [http://www.ebi.ac.uk/pdbsum/2i7n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i7n OCA], [https://pdbe.org/2i7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i7n RCSB], [https://www.ebi.ac.uk/pdbsum/2i7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i7n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PANK1_HUMAN PANK1_HUMAN]] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
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[[https://www.uniprot.org/uniprot/PANK1_HUMAN PANK1_HUMAN]] Plays a role in the physiological regulation of the intracellular CoA concentration (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Pantothenate kinase|Pantothenate kinase]]
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*[[Pantothenate kinase 3D structures|Pantothenate kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Pantothenate kinase]]
[[Category: Pantothenate kinase]]
[[Category: Allali-Hassani, A]]
[[Category: Allali-Hassani, A]]

Revision as of 07:29, 24 March 2021

Crystal structure of human PANK1 alpha: the catalytic core domain in complex with AcCoA

PDB ID 2i7n

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