This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2i2r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Crystal structure of the KChIP1/Kv4.3 T1 complex==
==Crystal structure of the KChIP1/Kv4.3 T1 complex==
-
<StructureSection load='2i2r' size='340' side='right' caption='[[2i2r]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
+
<StructureSection load='2i2r' size='340' side='right'caption='[[2i2r]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2i2r]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I2R FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2i2r]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I2R FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kcnd3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), KCNIP1, KCHIP1, VABP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kcnd3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), KCNIP1, KCHIP1, VABP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2r OCA], [http://pdbe.org/2i2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i2r RCSB], [http://www.ebi.ac.uk/pdbsum/2i2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i2r ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2r OCA], [https://pdbe.org/2i2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i2r RCSB], [https://www.ebi.ac.uk/pdbsum/2i2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i2r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/KCND3_RAT KCND3_RAT]] Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.<ref>PMID:8831489</ref> <ref>PMID:8734615</ref> <ref>PMID:9001401</ref> <ref>PMID:9450548</ref> [[http://www.uniprot.org/uniprot/KCIP1_HUMAN KCIP1_HUMAN]] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface.<ref>PMID:10676964</ref> <ref>PMID:11423117</ref> <ref>PMID:12829703</ref>
+
[[https://www.uniprot.org/uniprot/KCND3_RAT KCND3_RAT]] Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.<ref>PMID:8831489</ref> <ref>PMID:8734615</ref> <ref>PMID:9001401</ref> <ref>PMID:9450548</ref> [[https://www.uniprot.org/uniprot/KCIP1_HUMAN KCIP1_HUMAN]] Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface.<ref>PMID:10676964</ref> <ref>PMID:11423117</ref> <ref>PMID:12829703</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 31: Line 31:
==See Also==
==See Also==
-
*[[Potassium Channel|Potassium Channel]]
+
*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
Line 38: Line 38:
[[Category: Buffalo rat]]
[[Category: Buffalo rat]]
[[Category: Human]]
[[Category: Human]]
 +
[[Category: Large Structures]]
[[Category: Findeisen, F]]
[[Category: Findeisen, F]]
[[Category: Minor, D L]]
[[Category: Minor, D L]]

Revision as of 07:26, 24 March 2021

Crystal structure of the KChIP1/Kv4.3 T1 complex

PDB ID 2i2r

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i2r"
Personal tools