2i6e

<StructureSection load='2i6e' size='340' side='right' caption='[[2i6e]], [[Resolution|resolution]] 2.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[2i6e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_radiodurans"_raj_et_al._1960 "micrococcus radiodurans" raj et al. 1960]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2I6E FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6e OCA], [http://pdbe.org/2i6e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2i6e RCSB], [http://www.ebi.ac.uk/pdbsum/2i6e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2i6e ProSAT], [http://www.topsan.org/Proteins/NYSGXRC/2i6e TOPSAN]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/Q9RXE3_DEIRA Q9RXE3_DEIRA]] Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).[HAMAP-Rule:MF_00995]

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== Publication Abstract from PubMed ==

BACKGROUND: Pfam is a comprehensive collection of protein domains and families, with a range of well-established information including genome annotation. Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of two proteins from Deinococcus radiodurans and Streptomyces coelicolor belonging to Pfam protein family DUF178 (ID: PF02621) have been determined using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on the structure, we have identified the putative function for this family of protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably similar to Pfam family DUF191 suggesting that the sequence-based classification alone may not be sufficient to classify proteins into Pfam families.

X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family.,Tyagi R, Burley SK, Swaminathan S BMC Struct Biol. 2007 Oct 1;7:62. PMID:17908300<ref>PMID:17908300</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 2i6e" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Micrococcus radiodurans raj et al. 1960]]

[[Category: Burley, S K]]

[[Category: Kumaran, D]]

[[Category: Structural genomic]]

[[Category: Swaminathan, S]]

[[Category: Tyagi, R]]

[[Category: Unknown function]]