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2hw5
From Proteopedia
(Difference between revisions)
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==The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1== | ==The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1== | ||
| - | <StructureSection load='2hw5' size='340' side='right' caption='[[2hw5]], [[Resolution|resolution]] 2.55Å' scene=''> | + | <StructureSection load='2hw5' size='340' side='right'caption='[[2hw5]], [[Resolution|resolution]] 2.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2hw5]] is a 6 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2hw5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HW5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COO:CROTONYL+COENZYME+A'>COO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COO:CROTONYL+COENZYME+A'>COO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECHS1 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECHS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Enoyl-CoA_hydratase Enoyl-CoA hydratase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.17 4.2.1.17] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hw5 OCA], [https://pdbe.org/2hw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hw5 RCSB], [https://www.ebi.ac.uk/pdbsum/2hw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hw5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ECHM_HUMAN ECHM_HUMAN]] Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Enoyl-CoA hydratase|Enoyl-CoA hydratase]] | + | *[[Enoyl-CoA hydratase 3D structures|Enoyl-CoA hydratase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Enoyl-CoA hydratase]] | [[Category: Enoyl-CoA hydratase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C]] | [[Category: Arrowsmith, C]] | ||
[[Category: Debreczeni, J]] | [[Category: Debreczeni, J]] | ||
Revision as of 07:22, 24 March 2021
The crystal structure of human enoyl-coenzyme A (CoA) hydratase short chain 1, ECHS1
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Categories: Enoyl-CoA hydratase | Human | Large Structures | Arrowsmith, C | Debreczeni, J | Delft, F von | Edwards, A | Gileadi, O | Gorrec, F | Kavanagh, K | Niesen, F | Oppermann, U | Pike, A C.W | Structural genomic | Salah, E | Sundstrom, M | Turnbull, A P | Ugochukwu, E | Umeano, C | Weigelt, J | Beta-oxidation | Coa | Enoyl-coa hydratase | Fatty acid metabolism | Hydratase/isomerase superfamily | Lyase | Sgc
