This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2if5
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Structure of the POZ domain of human LRF, a master regulator of oncogenesis== | ==Structure of the POZ domain of human LRF, a master regulator of oncogenesis== | ||
| - | <StructureSection load='2if5' size='340' side='right' caption='[[2if5]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='2if5' size='340' side='right'caption='[[2if5]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2if5]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2if5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IF5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZBTB7A, FBI1, LRF, ZBTB7 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZBTB7A, FBI1, LRF, ZBTB7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2if5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2if5 OCA], [https://pdbe.org/2if5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2if5 RCSB], [https://www.ebi.ac.uk/pdbsum/2if5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2if5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ZBT7A_HUMAN ZBT7A_HUMAN]] Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 34: | Line 34: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Schubot, F D]] | [[Category: Schubot, F D]] | ||
[[Category: Tropea, J]] | [[Category: Tropea, J]] | ||
Revision as of 11:14, 31 March 2021
Structure of the POZ domain of human LRF, a master regulator of oncogenesis
| |||||||||||
