2ns1
From Proteopedia
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'''Crystal structure of the e. coli ammonia channel AMTB complexed with the signal transduction protein GLNK''' | '''Crystal structure of the e. coli ammonia channel AMTB complexed with the signal transduction protein GLNK''' | ||
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[[Category: III, J O.Connell.]] | [[Category: III, J O.Connell.]] | ||
[[Category: Stroud, R M.]] | [[Category: Stroud, R M.]] | ||
| - | [[Category: | + | [[Category: Adp]] |
| - | [[Category: | + | [[Category: Ammonia]] |
| - | [[Category: | + | [[Category: Bog]] |
| - | [[Category: | + | [[Category: Center for structures of membrane protein]] |
| - | [[Category: | + | [[Category: Channel]] |
| - | [[Category: | + | [[Category: Csmp]] |
| - | [[Category: | + | [[Category: Inhibitor]] |
| - | [[Category: | + | [[Category: Membrane protein]] |
| - | [[Category: | + | [[Category: Protein structure initiative]] |
| - | [[Category: | + | [[Category: Protein-protein complex]] |
| - | [[Category: | + | [[Category: Psi-2]] |
| - | [[Category: | + | [[Category: Regulatory]] |
| - | [[Category: | + | [[Category: Signal protein]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:50:27 2008'' | |
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Revision as of 06:50, 4 May 2008
Crystal structure of the e. coli ammonia channel AMTB complexed with the signal transduction protein GLNK
Overview
Ammonia conductance is highly regulated. A P(II) signal transduction protein, GlnK, is the final regulator of transmembrane ammonia conductance by the ammonia channel AmtB in Escherichia coli. The complex formed between AmtB and inhibitory GlnK at 1.96-A resolution shows that the trimeric channel is blocked directly by GlnK and how, in response to intracellular nitrogen status, the ability of GlnK to block the channel is regulated by uridylylation/deuridylylation at Y51. ATP and Mg(2+) augment the interaction of GlnK. The hydrolyzed product, adenosine 5'-diphosphate orients the surface of GlnK for AmtB blockade. 2-Oxoglutarate diminishes AmtB/GlnK association, and sites for 2-oxoglutarate are evaluated.
About this Structure
2NS1 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A., Gruswitz F, O'Connell J 3rd, Stroud RM, Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):42-7. Epub 2006 Dec 26. PMID:17190799 Page seeded by OCA on Sun May 4 09:50:27 2008
Categories: Escherichia coli | Protein complex | CSMP, Center for Structures of Membrane Proteins. | Gruswitz, F. | III, J O.Connell. | Stroud, R M. | Adp | Ammonia | Bog | Center for structures of membrane protein | Channel | Csmp | Inhibitor | Membrane protein | Protein structure initiative | Protein-protein complex | Psi-2 | Regulatory | Signal protein | Structural genomic
