6d4a
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cell Surface Receptor with Bound Ligand at 1.75-A Resolution== | |
| - | + | <StructureSection load='6d4a' size='340' side='right'caption='[[6d4a]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6d4a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D4A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D4A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FVP:2-aminoethyl+5-{[(4-cyclohexyl-1H-1,2,3-triazol-1-yl)acetyl]amino}-3,5,9-trideoxy-9-[(4-hydroxy-3,5-dimethylbenzene-1-carbonyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2- 6)-beta-D-galactopyranosyl-(1- 4)-beta-D-glucopyranoside'>FVP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6d48|6d48]], [[6d49|6d49]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d4a OCA], [http://pdbe.org/6d4a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d4a RCSB], [http://www.ebi.ac.uk/pdbsum/6d4a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d4a ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD33_HUMAN CD33_HUMAN]] Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).<ref>PMID:10556798</ref> <ref>PMID:11320212</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hermans, S J]] | ||
| + | [[Category: Miles, L A]] | ||
| + | [[Category: Parker, M W]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Receptor]] | ||
| + | [[Category: Sialic acid binding]] | ||
| + | [[Category: Siglec]] | ||
| + | [[Category: Transmembrane]] | ||
Revision as of 05:53, 17 April 2019
Cell Surface Receptor with Bound Ligand at 1.75-A Resolution
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