2ns3
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:2ns3.jpg|left|200px]] | [[Image:2ns3.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_2ns3", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_2ns3| PDB=2ns3 | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Solution structure of ribbon BuIA''' | '''Solution structure of ribbon BuIA''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 2NS3 is a [[Single protein]] structure | + | 2NS3 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NS3 OCA]. |
==Reference== | ==Reference== | ||
| Line 33: | Line 30: | ||
[[Category: Nevin, S T.]] | [[Category: Nevin, S T.]] | ||
[[Category: Tan, C C.]] | [[Category: Tan, C C.]] | ||
| - | [[Category: | + | [[Category: Ribbon disulfide connectivity]] |
| - | [[Category: | + | [[Category: Toxin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:50:29 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:50, 4 May 2008
Solution structure of ribbon BuIA
Overview
BACKGROUND: Alpha-conotoxins have exciting therapeutic potential based on their high selectivity and affinity for nicotinic acetylcholine receptors. The spacing between the cysteine residues in alpha-conotoxins is variable, leading to the classification of sub-families. BuIA is the only alpha-conotoxin containing a 4/4 cysteine spacing and thus it is of significant interest to examine the structure of this conotoxin. RESULTS: In the current study we show the native globular disulfide connectivity of BuIA displays multiple conformations in solution whereas the non-native ribbon isomer has a single well-defined conformation. Despite having multiple conformations in solution the globular form of BuIA displays activity at the nicotinic acetylcholine receptor, contrasting with the lack of activity of the structurally well-defined ribbon isomer. CONCLUSION: These findings are opposite to the general trends observed for alpha-conotoxins where the native isomers have well-defined structures and the ribbon isomers are generally disordered. This study thus highlights the influence of the disulfide connectivity of BuIA on the dynamics of the three-dimensional structure.
About this Structure
2NS3 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics., Jin AH, Brandstaetter H, Nevin ST, Tan CC, Clark RJ, Adams DJ, Alewood PF, Craik DJ, Daly NL, BMC Struct Biol. 2007 Apr 20;7:28. PMID:17445276 Page seeded by OCA on Sun May 4 09:50:29 2008
