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6gz6

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m (Protected "6gz6" [edit=sysop:move=sysop])
Current revision (06:47, 24 April 2019) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6gz6 is ON HOLD
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==Structure of a left-handed G-quadruplex==
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<StructureSection load='6gz6' size='340' side='right'caption='[[6gz6]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6gz6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GZ6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GZ6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gz6 OCA], [http://pdbe.org/6gz6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gz6 RCSB], [http://www.ebi.ac.uk/pdbsum/6gz6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gz6 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Recently, we observed the first example of a left-handed G-quadruplex structure formed by natural DNA, named Z-G4. We analysed the Z-G4 structure and inspected its primary 28-nt sequence in order to identify motifs that convey the unique left-handed twist. Using CD, NMR spectroscopy and X-ray crystallography, we revealed a minimal sequence motif of 12 nt GTGGTGGTGGTG for the left-handed DNA G-quadruplex formation, which is found to be highly abundant in the human genome. A systematic analysis of thymine loop mutations revealed a moderate sequence tolerance, which would further broaden the space of sequences prone to left-handed G-quadruplex formation.
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Authors:
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A minimal sequence for left-handed G-quadruplex formation.,Phan AT Angew Chem Int Ed Engl. 2018 Nov 27. doi: 10.1002/anie.201812628. PMID:30481397<ref>PMID:30481397</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 6gz6" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Bakalar, B]]
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[[Category: Heddi, B]]
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[[Category: Mechulam, Y]]
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[[Category: Phan, A T]]
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[[Category: Schmitt, E]]
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[[Category: Dna]]
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[[Category: G-quadruplex]]

Current revision

Structure of a left-handed G-quadruplex

PDB ID 6gz6

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