2nw3

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[[Image:2nw3.gif|left|200px]]
[[Image:2nw3.gif|left|200px]]
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{{Structure
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|PDB= 2nw3 |SIZE=350|CAPTION= <scene name='initialview01'>2nw3</scene>, resolution 1.700&Aring;
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The line below this paragraph, containing "STRUCTURE_2nw3", creates the "Structure Box" on the page.
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|SITE=
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|GENE= HLA-B, HLAB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2nw3| PDB=2nw3 | SCENE= }}
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|RELATEDENTRY=[[2nw2|2NW2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2nw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nw3 OCA], [http://www.ebi.ac.uk/pdbsum/2nw3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2nw3 RCSB]</span>
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'''Crystal structure of HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A'''
'''Crystal structure of HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A'''
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[[Category: Rossjohn, J.]]
[[Category: Rossjohn, J.]]
[[Category: Tynan, F E.]]
[[Category: Tynan, F E.]]
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[[Category: hla-b*3508]]
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[[Category: Hla-b*3508]]
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[[Category: mhc]]
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[[Category: Mhc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 09:58:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:09:20 2008''
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Revision as of 06:58, 4 May 2008

Image:2nw3.gif

Template:STRUCTURE 2nw3

Crystal structure of HLA-B*3508 presenting EBV peptide EPLPQGQLTAY at 1.7A


Overview

Plasticity of the T cell receptor (TCR) is a hallmark of major histocompatibility complex (MHC)-restricted T cell recognition. However, it is unclear whether interactions of TCR and peptide-MHC class I (pMHCI) always conform to this paradigm. Here we describe the structure of a TCR, ELS4, in its non-ligand-bound form and in complex with a prominent 'bulged' Epstein-Barr virus peptide bound to HLA-B(*)3501. This complex was atypical of previously characterized TCR-pMHCI interactions in that a rigid face of the TCR crumpled the bulged antigenic determinant. This peptide 'bulldozing' created a more featureless pMHCI determinant, allowing the TCR to maximize MHC class I contacts essential for MHC class I restriction of TCR recognition. Our findings represent a mechanism of antigen recognition whereby the plasticity of the T cell response is dictated mainly by adjustments in the MHC-bound peptide.

About this Structure

2NW3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule., Tynan FE, Reid HH, Kjer-Nielsen L, Miles JJ, Wilce MC, Kostenko L, Borg NA, Williamson NA, Beddoe T, Purcell AW, Burrows SR, McCluskey J, Rossjohn J, Nat Immunol. 2007 Mar;8(3):268-76. Epub 2007 Jan 28. PMID:17259989 Page seeded by OCA on Sun May 4 09:58:47 2008

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