2ny7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2ny7.gif|left|200px]]
[[Image:2ny7.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2ny7 |SIZE=350|CAPTION= <scene name='initialview01'>2ny7</scene>, resolution 2.30&Aring;
+
The line below this paragraph, containing "STRUCTURE_2ny7", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2ny7| PDB=2ny7 | SCENE= }}
-
|RELATEDENTRY=[[1hzh|1HZH]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ny7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ny7 OCA], [http://www.ebi.ac.uk/pdbsum/2ny7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ny7 RCSB]</span>
+
-
}}
+
'''HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody b12'''
'''HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody b12'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
2NY7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY7 OCA].
+
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NY7 OCA].
==Reference==
==Reference==
Structural definition of a conserved neutralization epitope on HIV-1 gp120., Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD, Nature. 2007 Feb 15;445(7129):732-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17301785 17301785]
Structural definition of a conserved neutralization epitope on HIV-1 gp120., Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD, Nature. 2007 Feb 15;445(7129):732-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17301785 17301785]
-
[[Category: Homo sapiens]]
 
-
[[Category: Human immunodeficiency virus 1]]
 
-
[[Category: Protein complex]]
 
[[Category: Arthos, J.]]
[[Category: Arthos, J.]]
[[Category: Burton, D R.]]
[[Category: Burton, D R.]]
Line 42: Line 36:
[[Category: Zhou, T.]]
[[Category: Zhou, T.]]
[[Category: Zwick, M B.]]
[[Category: Zwick, M B.]]
-
[[Category: b12]]
+
[[Category: B12]]
-
[[Category: broadly neutralizing antibody]]
+
[[Category: Broadly neutralizing antibody]]
-
[[Category: gp120]]
+
[[Category: Gp120]]
-
[[Category: hiv]]
+
[[Category: Hiv]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:04:00 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:10:06 2008''
+

Revision as of 07:04, 4 May 2008

Image:2ny7.gif

Template:STRUCTURE 2ny7

HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody b12


Overview

The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutralization. Despite this complexity, the HIV-1 Env must retain conserved determinants that mediate CD4 binding. To evaluate how these determinants might provide opportunities for antibody recognition, we created variants of gp120 stabilized in the CD4-bound state, assessed binding of CD4 and of receptor-binding-site antibodies, and determined the structure at 2.3 A resolution of the broadly neutralizing antibody b12 in complex with gp120. b12 binds to a conformationally invariant surface that overlaps a distinct subset of the CD4-binding site. This surface is involved in the metastable attachment of CD4, before the gp120 rearrangement required for stable engagement. A site of vulnerability, related to a functional requirement for efficient association with CD4, can therefore be targeted by antibody to neutralize HIV-1.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural definition of a conserved neutralization epitope on HIV-1 gp120., Zhou T, Xu L, Dey B, Hessell AJ, Van Ryk D, Xiang SH, Yang X, Zhang MY, Zwick MB, Arthos J, Burton DR, Dimitrov DS, Sodroski J, Wyatt R, Nabel GJ, Kwong PD, Nature. 2007 Feb 15;445(7129):732-7. PMID:17301785 Page seeded by OCA on Sun May 4 10:04:00 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ny7"
Personal tools