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2o0t

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[[Image:2o0t.gif|left|200px]]
[[Image:2o0t.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2o0t |SIZE=350|CAPTION= <scene name='initialview01'>2o0t</scene>, resolution 2.33&Aring;
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The line below this paragraph, containing "STRUCTURE_2o0t", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Diaminopimelate_decarboxylase Diaminopimelate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.20 4.1.1.20] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= lysA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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-->
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|DOMAIN=
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{{STRUCTURE_2o0t| PDB=2o0t | SCENE= }}
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|RELATEDENTRY=[[1hkv|1HKV]], [[1hkw|1HKW]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o0t OCA], [http://www.ebi.ac.uk/pdbsum/2o0t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o0t RCSB]</span>
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}}
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'''The three dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation'''
'''The three dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation'''
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[[Category: Weiss, M S.]]
[[Category: Weiss, M S.]]
[[Category: Weyand, S.]]
[[Category: Weyand, S.]]
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[[Category: decarboxylase]]
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[[Category: Decarboxylase]]
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[[Category: lysine biosynthesis]]
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[[Category: Lysine biosynthesis]]
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[[Category: plp binding enzyme]]
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[[Category: Plp binding enzyme]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: tb structural genomics consortium]]
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[[Category: Tb structural genomics consortium]]
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[[Category: tbsgc]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:09:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:11:04 2008''
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Revision as of 07:09, 4 May 2008

Image:2o0t.gif

Template:STRUCTURE 2o0t

The three dimensional structure of diaminopimelate decarboxylase from Mycobacterium tuberculosis reveals a tetrameric enzyme organisation


Overview

Diaminopimelate decarboxylase from Mycobacterium tuberculosis (LysA, DAPDC, Rv1293) has been cloned and heterologously expressed in Escherichia coli, purified using standard chromatographic techniques and crystallized. Preliminary diffraction data analysis suggests the presence of a homotetramer in the asymmetric unit.

About this Structure

2O0T is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of LysA (Rv1293) from Mycobacterium tuberculosis., Kefala G, Perry LJ, Weiss MS, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Aug 1;61(Pt, 8):782-4. Epub 2005 Jul 30. PMID:16511157 Page seeded by OCA on Sun May 4 10:09:53 2008

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