2o27
From Proteopedia
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[[Image:2o27.gif|left|200px]] | [[Image:2o27.gif|left|200px]] | ||
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'''Structure of a class III RTK signaling assembly''' | '''Structure of a class III RTK signaling assembly''' | ||
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[[Category: Liu, H.]] | [[Category: Liu, H.]] | ||
[[Category: 4-helix bundle]] | [[Category: 4-helix bundle]] | ||
| - | [[Category: | + | [[Category: Class iii]] |
| - | [[Category: | + | [[Category: Cytokine]] |
| - | [[Category: | + | [[Category: Growth factor]] |
| - | [[Category: | + | [[Category: Receptor tyrosine kinase]] |
| - | [[Category: | + | [[Category: Receptor/ligand complex]] |
| - | [[Category: | + | [[Category: Stem cell factor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:13:30 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:13, 4 May 2008
Structure of a class III RTK signaling assembly
Overview
Stem cell factor (SCF) binds to and activates the KIT receptor, a class III receptor tyrosine kinase (RTK), to stimulate diverse processes including melanogenesis, gametogenesis and hematopoeisis. Dysregulation of KIT activation is associated with many cancers. We report a 2.5 A crystal structure of the functional core of SCF bound to the extracellular ligand-binding domains of KIT. The structure reveals a 'wrapping' SCF-recognition mode by KIT, in which KIT adopts a bent conformation to facilitate each of its first three immunoglobulin (Ig)-like domains to interact with SCF. Three surface epitopes on SCF, an extended loop, the B and C helices, and the N-terminal segment, contact distinct KIT domains, with two of the epitopes undergoing large conformational changes upon receptor binding. The SCF/KIT complex reveals a unique RTK dimerization assembly, and a novel recognition mode between four-helix bundle cytokines and Ig-family receptors. It serves as a framework for understanding the activation mechanisms of class III RTKs.
About this Structure
2O27 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases., Liu H, Chen X, Focia PJ, He X, EMBO J. 2007 Feb 7;26(3):891-901. Epub 2007 Jan 25. PMID:17255936 Page seeded by OCA on Sun May 4 10:13:30 2008
