6fej
From Proteopedia
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==Anabaena Apo-C-Terminal Domain Homolog Protein== | ==Anabaena Apo-C-Terminal Domain Homolog Protein== | ||
| - | <StructureSection load='6fej' size='340' side='right' caption='[[6fej]], [[Resolution|resolution]] 2.75Å' scene=''> | + | <StructureSection load='6fej' size='340' side='right'caption='[[6fej]], [[Resolution|resolution]] 2.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6fej]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FEJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6fej]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Anabaena_7120 Anabaena 7120]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FEJ FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=URE:UREA'>URE</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=URE:UREA'>URE</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">all4940 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=103690 Anabaena 7120])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fej OCA], [http://pdbe.org/6fej PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fej RCSB], [http://www.ebi.ac.uk/pdbsum/6fej PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fej ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fej OCA], [http://pdbe.org/6fej PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fej RCSB], [http://www.ebi.ac.uk/pdbsum/6fej PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fej ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A recently reported family of soluble cyanobacterial carotenoproteins, homologs of the C-terminal domain (CTDH) of the photoprotective Orange Carotenoid Protein, is suggested to mediate carotenoid transfer from the thylakoid membrane to the Helical Carotenoid Proteins, which are paralogs of the N-terminal domain of the OCP. Here we present the three-dimensional structure of a carotenoid-free CTDH variant from Anabaena (Nostoc) PCC 7120. This CTDH contains a cysteine residue at position 103. Two dimer-forming interfaces were identified, one stabilized by a disulfide bond between monomers and the second between each monomer's beta-sheets, both compatible with small-angle X-ray scattering data and likely representing intermediates of carotenoid transfer processes. The crystal structure revealed a major positional change of the C-terminal tail. Further mutational analysis revealed the importance of the C-terminal tail in both carotenoid uptake and delivery. These results have allowed us to suggest a detailed model for carotenoid transfer via these soluble proteins. | ||
| + | |||
| + | Structural rearrangements in the C-terminal domain homolog of Orange Carotenoid Protein are crucial for carotenoid transfer.,Harris D, Wilson A, Muzzopappa F, Sluchanko NN, Friedrich T, Maksimov EG, Kirilovsky D, Adir N Commun Biol. 2018 Aug 27;1:125. doi: 10.1038/s42003-018-0132-5. eCollection 2018. PMID:30272005<ref>PMID:30272005</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6fej" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Anabaena 7120]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Adir, N]] | [[Category: Adir, N]] | ||
[[Category: Harris, D]] | [[Category: Harris, D]] | ||
Revision as of 06:03, 10 October 2019
Anabaena Apo-C-Terminal Domain Homolog Protein
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