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Importin

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== Structural highlights ==
== Structural highlights ==
 +
 +
==3D structures of importin==
 +
[[Importin 3D structures]]
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</StructureSection>
</StructureSection>
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*''IPO-α 1 complex with NLS peptide''
*''IPO-α 1 complex with NLS peptide''
 +
**[[4b18]] – hIPO NLS-binding domain + telomerase reverse transcriptase<br />
 +
**[[4wv6]] – hIPO NLS-binding domain + TFIID<br />
 +
**[[6bw0]] – hIPO NLS-binding domain + Nipa virus peptide<br />
 +
**[[6bw1]] – hIPO NLS-binding domain + Hendra virus peptide<br />
 +
**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />
 +
**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />
**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain + dUTPase<br />
**[[4mz5]], [[4mz6]] – mIPO NLS-binding domain + dUTPase<br />
**[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1<br />
**[[4oih]] – mIPO NLS-binding domain + guanine nucleotide exchange factor SRM1<br />
Line 70: Line 80:
**[[5klr]], [[5klt]] – mIPO NLS-binding domain + NLS <br />
**[[5klr]], [[5klt]] – mIPO NLS-binding domain + NLS <br />
**[[5k9s]] – mIPO NLS-binding domain + HNF-b <br />
**[[5k9s]] – mIPO NLS-binding domain + HNF-b <br />
-
**[[4b18]] – hIPO NLS-binding domain + telomerase reverse transcriptase<br />
+
**[[6iu7]], [[6iua]] – mIPO NLS-binding domain + TP53-binding protein <br />
-
**[[4wv6]] – hIPO NLS-binding domain + TFIID<br />
+
-
**[[6bw0]] – hIPO NLS-binding domain + Nipa virus peptide<br />
+
-
**[[6bw1]] – hIPO NLS-binding domain + Hendra virus peptide<br />
+
**[[5w41]] – mIPO NLS-binding domain + Zika virus peptide <br />
**[[5w41]] – mIPO NLS-binding domain + Zika virus peptide <br />
**[[5v5o]], [[5v5p]] – mIPO NLS-binding domain + influenza virus peptide <br />
**[[5v5o]], [[5v5p]] – mIPO NLS-binding domain + influenza virus peptide <br />
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**[[5u5p]], [[5u5r]] – mIPO NLS-binding domain + MLH1 peptide <br />
**[[5u5p]], [[5u5r]] – mIPO NLS-binding domain + MLH1 peptide <br />
**[[5gxw]] – mIPO NLS-binding domain + NUMA peptide <br />
**[[5gxw]] – mIPO NLS-binding domain + NUMA peptide <br />
-
**[[5w4e]], [[5w4f]], [[5w4g]] – hIPO NLS-binding domain + polymerase peptide<br />
 
-
**[[5h43]] – hIPO NLS-binding domain + histone acetyltransferase KAT8<br />
 
**[[4b8o]] – rIPO NLS-binding domain + SV40<br />
**[[4b8o]] – rIPO NLS-binding domain + SV40<br />
**[[4b8p]] – rIPO NLS-binding domain + A89<br />
**[[4b8p]] – rIPO NLS-binding domain + A89<br />
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*''IPO-β 1 complex with protein''
*''IPO-β 1 complex with protein''
-
**[[1qgx]], [[1qgr]] – hIPO + IPO-α 2 IBB domain<br />
+
**[[1qgx]], [[1qgk]] – hIPO + IPO-α 2 IBB domain<br />
**[[1ibr]] – hIPO + GTPase Ran<br />
**[[1ibr]] – hIPO + GTPase Ran<br />
**[[2bku]], [[3ea5]] – yIPO + GTPase Ran<br />
**[[2bku]], [[3ea5]] – yIPO + GTPase Ran<br />
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**[[5xah]] – hIPO residues 668-1081 <br />
**[[5xah]] – hIPO residues 668-1081 <br />
**[[5xbk]] – hIPO residues 668-1081 + histone H3 peptide <br />
**[[5xbk]] – hIPO residues 668-1081 + histone H3 peptide <br />
 +
 +
*IPO-7
 +
 +
**[[6n88]] – IPO + hIPO-90 + histone H1.0 – frog – Cryo EM <br />
 +
 +
*IPO-9
 +
 +
**[[6n1z]] – hIPO + histone H2A + histone H2B <br />
*IPO-12 (Transportin-3)
*IPO-12 (Transportin-3)
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**[[2xwu]] – hIPO + UBC9<br />
**[[2xwu]] – hIPO + UBC9<br />
**[[3zjy]] – hIPO + GTPase Ran + EIF-1A<br />
**[[3zjy]] – hIPO + GTPase Ran + EIF-1A<br />
 +
 +
*IPO-90
 +
 +
**[[6n89]] – hIPO-90 + histone H1.0 – Cryo EM <br />
}}
}}

Revision as of 10:28, 27 August 2019

Structure of yeast importin α NLS-binding domain (grey) complex with nucleoplasmin peptide (green) (PDB code 1ee5).

Drag the structure with the mouse to rotate

3D structures of importin

Updated on 27-August-2019

References

  1. ↑ Mattaj IW, Englmeier L. Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem. 1998;67:265-306. PMID:9759490 doi:http://dx.doi.org/10.1146/annurev.biochem.67.1.265
  2. ↑ Pumroy RA, Cingolani G. Diversification of importin-alpha isoforms in cellular trafficking and disease states. Biochem J. 2015 Feb 15;466(1):13-28. doi: 10.1042/BJ20141186. PMID:25656054 doi:http://dx.doi.org/10.1042/BJ20141186

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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