This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Sandbox7878
From Proteopedia
| Line 1: | Line 1: | ||
| - | == | + | == Overview == |
<Structure load='4ny4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='4ny4' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
| - | == | + | == Mechanism == |
asdfadf | asdfadf | ||
| - | == | + | == Structure and Sequence == |
| + | The gene encoding CYP3A4 is located on chromosome 7 in the human genome[6] and it has been found that there are significant variants of the protein correlating to race [7]. This finding is relevant due to the proteins altered ability to react with substrates such as testosterone [8]. | ||
| - | + | The | |
| - | == | + | Show:Asymmetric Unit Biological Assembly, QSbio confidence: Low |
| + | Export Animated Image | ||
| + | alpha helices can be seen colored in rainbow succession from the N to C terminus. The protein pocket, where the reactions are catalyzed, more specifically, the heme binding site contains twenty-two residues [5] but the main interaction is with a Cysteine at position 442, which coordinates with iron. | ||
| + | |||
| + | == Drug Metabolism == | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 02:52, 20 July 2018
Contents |
Overview
|
Mechanism
asdfadf
Structure and Sequence
The gene encoding CYP3A4 is located on chromosome 7 in the human genome[6] and it has been found that there are significant variants of the protein correlating to race [7]. This finding is relevant due to the proteins altered ability to react with substrates such as testosterone [8].
The Show:Asymmetric Unit Biological Assembly, QSbio confidence: Low
Export Animated Image
alpha helices can be seen colored in rainbow succession from the N to C terminus. The protein pocket, where the reactions are catalyzed, more specifically, the heme binding site contains twenty-two residues [5] but the main interaction is with a Cysteine at position 442, which coordinates with iron.
