This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Isopropylmalate dehydrogenase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
== Structural highlights ==
== Structural highlights ==
-
<scene name='49/490899/Cv/2'>3-isopropylmalate dehydrogenase complex with 3-isopropylmalate, glycerol, NAD, PMSF, Mn+2 and K- ions</scene>.
+
<scene name='49/490899/Cv/11'>3-isopropylmalate dehydrogenase complex with 3-isopropylmalate, glycerol, NAD, PMSF, Mn+2 and K- ions</scene>.
IMDH active site containing the <scene name='49/490899/Cv/9'>NAD cofactor is located between 2 subunits</scene> and contains the substrate and Mn+2 and K- ions<ref>PMID:25211160</ref>. Water molecules shown as red spheres.
IMDH active site containing the <scene name='49/490899/Cv/9'>NAD cofactor is located between 2 subunits</scene> and contains the substrate and Mn+2 and K- ions<ref>PMID:25211160</ref>. Water molecules shown as red spheres.
-
<scene name='49/490899/Cv/4'>MN coordination site</scene>.
+
<scene name='49/490899/Cv/12'>MN coordination site</scene>.
-
<scene name='49/490899/Cv/6'>K coordination site</scene>.
+
<scene name='49/490899/Cv/13'>K coordination site</scene>.
-
<scene name='49/490899/Cv/5'>3-isopropylmalate binding site</scene>.
+
<scene name='49/490899/Cv/14'>3-isopropylmalate binding site</scene>.
-
<scene name='49/490899/Cv/10'>Whole IMDH active site</scene>.
+
<scene name='49/490899/Cv/15'>Whole IMDH active site</scene>.
</StructureSection>
</StructureSection>
==3D structures of isopropylmalate dehydrogenase==
==3D structures of isopropylmalate dehydrogenase==

Revision as of 10:03, 30 June 2019

3-isopropylmalate dehydrogenase complex with 3-isopropylmalate, glycerol, NAD, PMSF, Mn+2 and K+ ions (purple) (PDB entry 4f7i)

Drag the structure with the mouse to rotate

3D structures of isopropylmalate dehydrogenase

Updated on 30-June-2019

References

  1. ↑ Martignon S, Rossi F, Rizzi M. Expression, purification and characterisation of Haemophilus influenzae 3-isopropylmalate dehydrogenase (LeuB). Protein Pept Lett. 2007;14(8):822-7. PMID:17979826
  2. ↑ Pallo A, Olah J, Graczer E, Merli A, Zavodszky P, Weiss MS, Vas M. Structural and energetic basis of isopropylmalate dehydrogenase enzyme catalysis. FEBS J. 2014 Sep 11. doi: 10.1111/febs.13044. PMID:25211160 doi:http://dx.doi.org/10.1111/febs.13044

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Isopropylmalate_dehydrogenase"
Personal tools