6a73

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'''Unreleased structure'''
 
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The entry 6a73 is ON HOLD until Paper Publication
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==Complex structure of CSN2 with IP6==
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<StructureSection load='6a73' size='340' side='right'caption='[[6a73]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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Authors: Liu, L., Li, D., Rao, F., Wang, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6a73]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A73 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A73 FirstGlance]. <br>
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Description: Complex structure of CSN2 with IP6
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a73 OCA], [http://pdbe.org/6a73 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a73 RCSB], [http://www.ebi.ac.uk/pdbsum/6a73 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a73 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CSN2_HUMAN CSN2_HUMAN]] Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.<ref>PMID:9535219</ref> <ref>PMID:11285227</ref> <ref>PMID:11337588</ref> <ref>PMID:12732143</ref> <ref>PMID:12628923</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Lysozyme]]
[[Category: Li, D]]
[[Category: Li, D]]
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[[Category: Wang, T]]
 
[[Category: Liu, L]]
[[Category: Liu, L]]
[[Category: Rao, F]]
[[Category: Rao, F]]
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[[Category: Wang, T]]
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[[Category: Signaling protein]]

Revision as of 05:43, 3 July 2019

Complex structure of CSN2 with IP6

PDB ID 6a73

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