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2o9k

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[[Image:2o9k.gif|left|200px]]
[[Image:2o9k.gif|left|200px]]
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{{Structure
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|PDB= 2o9k |SIZE=350|CAPTION= <scene name='initialview01'>2o9k</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2o9k", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2o9k| PDB=2o9k | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o9k OCA], [http://www.ebi.ac.uk/pdbsum/2o9k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2o9k RCSB]</span>
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'''WDR5 in Complex with Dimethylated H3K4 Peptide'''
'''WDR5 in Complex with Dimethylated H3K4 Peptide'''
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==About this Structure==
==About this Structure==
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2O9K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 2H9O. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O9K OCA].
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2O9K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2h9o 2h9o]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O9K OCA].
==Reference==
==Reference==
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[[Category: Vedadi, M.]]
[[Category: Vedadi, M.]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
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[[Category: sgc]]
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[[Category: Sgc]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structural genomics consortium]]
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[[Category: Structural genomics consortium]]
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[[Category: wdr5]]
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[[Category: Wdr5]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:29:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:14:41 2008''
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Revision as of 07:29, 4 May 2008

Image:2o9k.gif

Template:STRUCTURE 2o9k

WDR5 in Complex with Dimethylated H3K4 Peptide


Overview

Histone methylation at specific lysine residues brings about various downstream events that are mediated by different effector proteins. The WD40 domain of WDR5 represents a new class of histone methyl-lysine recognition domains that is important for recruiting H3K4 methyltransferases to K4-dimethylated histone H3 tail as well as for global and gene-specific K4 trimethylation. Here we report the crystal structures of full-length WDR5, WDR5Delta23 and its complexes with unmodified, mono-, di- and trimethylated histone H3K4 peptides. The structures reveal that WDR5 is able to bind all of these histone H3 peptides, but only H3K4me2 peptide forms extra interactions with WDR5 by use of both water-mediated hydrogen bonding and the altered hydrophilicity of the modified lysine 4. We propose a mechanism for the involvement of WDR5 in binding and presenting histone H3K4 for further methylation as a component of MLL complexes.

About this Structure

2O9K is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 2h9o. Full crystallographic information is available from OCA.

Reference

Structural basis for molecular recognition and presentation of histone H3 by WDR5., Schuetz A, Allali-Hassani A, Martin F, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Arrowsmith CH, Min J, EMBO J. 2006 Sep 20;25(18):4245-52. Epub 2006 Aug 31. PMID:16946699 Page seeded by OCA on Sun May 4 10:29:36 2008

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