5xej
From Proteopedia
(Difference between revisions)
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==Crystal Structure of Macrophage Migration Inhibitory Factor bound to MTX== | ==Crystal Structure of Macrophage Migration Inhibitory Factor bound to MTX== | ||
- | <StructureSection load='5xej' size='340' side='right' caption='[[5xej]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='5xej' size='340' side='right'caption='[[5xej]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[5xej]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5cg4 5cg4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEJ OCA]. For a <b>guided tour on the structure components</b> use [http:// | + | <table><tr><td colspan='2'>[[5xej]] is a 3 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5cg4 5cg4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEJ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5XEJ FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6UV:(2~{R})-2-[[4-[[2,4-BIS(AZANYL)PTERIDIN-6-YL]METHYL-METHYL-AMINO]PHENYL]CARBONYLAMINO]PENTANEDIOIC+ACID'>6UV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6UV:(2~{R})-2-[[4-[[2,4-BIS(AZANYL)PTERIDIN-6-YL]METHYL-METHYL-AMINO]PHENYL]CARBONYLAMINO]PENTANEDIOIC+ACID'>6UV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cg4|5cg4]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5cg4|5cg4]]</td></tr> | ||
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http:// | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5xej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xej OCA], [http://pdbe.org/5xej PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xej RCSB], [http://www.ebi.ac.uk/pdbsum/5xej PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xej ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref> | [[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref> | ||
+ | |||
+ | ==See Also== | ||
+ | *[[Macrophage inhibitory factor 3D structures|Macrophage inhibitory factor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
+ | [[Category: Large Structures]] | ||
[[Category: Fukushima, K]] | [[Category: Fukushima, K]] | ||
[[Category: Takimoto-Kamimura, M]] | [[Category: Takimoto-Kamimura, M]] | ||
[[Category: Isomerase-inhibitor complex]] | [[Category: Isomerase-inhibitor complex]] |
Revision as of 06:47, 14 October 2020
Crystal Structure of Macrophage Migration Inhibitory Factor bound to MTX
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