5zb9

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<StructureSection load='5zb9' size='340' side='right' caption='[[5zb9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='5zb9' size='340' side='right' caption='[[5zb9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zb9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZB9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zb9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspfu Aspfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZB9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AFUA_5G09540 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=330879 ASPFU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zb9 OCA], [http://pdbe.org/5zb9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zb9 RCSB], [http://www.ebi.ac.uk/pdbsum/5zb9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zb9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zb9 OCA], [http://pdbe.org/5zb9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zb9 RCSB], [http://www.ebi.ac.uk/pdbsum/5zb9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zb9 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rtt109 is a unique histone acetyltransferase acetylating histone H3 lysine 56 (H3K56), a modification critical for DNA replication-coupled nucleosome assembly and genome stability. In cells, histone chaperone Asf1 is essential for H3K56 acetylation, yet the mechanisms for H3K56 specificity and Asf1 requirement remain unknown. We have determined the crystal structure of the Rtt109-Asf1-H3-H4 complex and found that unwinding of histone H3 alphaN, where K56 is normally located, and stabilization of the very C-terminal beta strand of histone H4 by Asf1 are prerequisites for H3K56 acetylation. Unexpectedly, an interaction between Rtt109 and the central helix of histone H3 is also required. The observed multiprotein, multisite substrate recognition mechanism among histone modification enzymes provides mechanistic understandings of Rtt109 and Asf1 in H3K56 acetylation, as well as valuable insights into substrate recognition by histone modification enzymes in general.
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Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109.,Zhang L, Serra-Cardona A, Zhou H, Wang M, Yang N, Zhang Z, Xu RM Cell. 2018 Aug 9;174(4):818-830.e11. doi: 10.1016/j.cell.2018.07.005. Epub 2018, Jul 26. PMID:30057113<ref>PMID:30057113</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5zb9" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Aspfu]]
[[Category: Serra-Cardona, A]]
[[Category: Serra-Cardona, A]]
[[Category: Wang, M]]
[[Category: Wang, M]]

Revision as of 06:30, 22 August 2018

Crystal structure of Rtt109 from Aspergillus fumigatus

5zb9, resolution 2.50Å

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