6e29

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<StructureSection load='6e29' size='340' side='right' caption='[[6e29]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='6e29' size='340' side='right' caption='[[6e29]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6e29]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E29 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6e29]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_117.65 Cbs 117.65]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E29 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e29 OCA], [http://pdbe.org/6e29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e29 RCSB], [http://www.ebi.ac.uk/pdbsum/6e29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e29 ProSAT]</span></td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MYCTH_2294520 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=78579 CBS 117.65])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e29 OCA], [http://pdbe.org/6e29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e29 RCSB], [http://www.ebi.ac.uk/pdbsum/6e29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e29 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The methylation of histone 3 lysine 4 (H3K4) is carried out by an evolutionarily conserved family of methyltransferases referred to as complex of proteins associated with Set1 (COMPASS). The activity of the catalytic SET domain (su(var)3-9, enhancer-of-zeste, and trithorax) is endowed through forming a complex with a set of core proteins that are widely shared from yeast to humans. We obtained cryo-electron microscopy (cryo-EM) maps of the yeast Set1/COMPASS core complex at overall 4.0- to 4.4-A resolution, providing insights into its structural organization and conformational dynamics. The Cps50 C-terminal tail weaves within the complex to provide a central scaffold for assembly. The SET domain, snugly positioned at the junction of the Y-shaped complex, is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3). The mobile SET-I motif of the SET domain is engaged by Cps30, explaining its key role in COMPASS catalytic activity toward higher H3K4 methylation states.
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Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.,Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G Cell. 2018 Aug 23;174(5):1117-1126.e12. doi: 10.1016/j.cell.2018.07.020. Epub, 2018 Aug 9. PMID:30100186<ref>PMID:30100186</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6e29" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cbs 117 65]]
[[Category: Brunzelle, J S]]
[[Category: Brunzelle, J S]]
[[Category: Couture, J F]]
[[Category: Couture, J F]]

Revision as of 07:59, 29 August 2018

Crystal structure of Myceliophteria_thermophila Cps50 (Swd1) beta-propeller domain

6e29, resolution 1.82Å

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