5zue

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Current revision (10:29, 27 March 2024) (edit) (undo)
 
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==GTP-bound, double-stranded, curved FtsZ protofilament structure==
==GTP-bound, double-stranded, curved FtsZ protofilament structure==
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<StructureSection load='5zue' size='340' side='right' caption='[[5zue]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='5zue' size='340' side='right'caption='[[5zue]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zue]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZUE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zue]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ZUE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ftsZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zue OCA], [http://pdbe.org/5zue PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zue RCSB], [http://www.ebi.ac.uk/pdbsum/5zue PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zue ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5zue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zue OCA], [https://pdbe.org/5zue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5zue RCSB], [https://www.ebi.ac.uk/pdbsum/5zue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5zue ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FTSZ_MYCTU FTSZ_MYCTU]] Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells (By similarity). Binds GTP and shows GTPase activity.[HAMAP-Rule:MF_00909]
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[https://www.uniprot.org/uniprot/FTSZ_MYCTU FTSZ_MYCTU] Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells (By similarity). Binds GTP and shows GTPase activity.[HAMAP-Rule:MF_00909]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The prokaryotic tubulin homolog FtsZ polymerizes into protofilaments, which further assemble into higher-order structures at future division sites to form the Z-ring, a dynamic structure essential for bacterial cell division. The precise nature of interactions between FtsZ protofilaments that organize the Z-ring and their physiological significance remain enigmatic. In this study, we solved two crystallographic structures of a pair of FtsZ protofilaments,and demonstrated that they assemble in an antiparallel manner through the formation of two different inter-protofilament lateral interfaces. Our in vivo photocrosslinking studies confirmed that such lateral interactions occur in living cells, and disruption of the lateral interactions rendered cells unable to divide. The inherently weak lateral interactions enable FtsZ protofilaments to self-organize into a dynamic Z-ring. These results have fundamental implications for our understanding of bacterial cell division and for developing antibiotics that target this key process.
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Lateral interactions between protofilaments of the bacterial tubulin homolog FtsZ are essential for cell division.,Guan F, Yu J, Yu J, Liu Y, Li Y, Feng XH, Huang KC, Chang Z, Ye S Elife. 2018 Jun 11;7. pii: 35578. doi: 10.7554/eLife.35578. PMID:29889022<ref>PMID:29889022</ref>
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==See Also==
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*[[Cell division protein 3D structures|Cell division protein 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5zue" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: Chang, Z]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Feng, X H]]
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[[Category: Chang Z]]
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[[Category: Guan, F]]
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[[Category: Feng XH]]
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[[Category: Huang, K C]]
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[[Category: Guan F]]
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[[Category: Li, Y]]
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[[Category: Huang KC]]
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[[Category: Liu, Y]]
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[[Category: Li Y]]
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[[Category: Ye, S]]
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[[Category: Liu Y]]
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[[Category: Yu, J]]
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[[Category: Ye S]]
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[[Category: Bacterial cell division]]
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[[Category: Yu J]]
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[[Category: Cytosolic protein]]
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[[Category: Ftsz]]
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[[Category: Gtpase]]
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Current revision

GTP-bound, double-stranded, curved FtsZ protofilament structure

PDB ID 5zue

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