2ocj

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[[Image:2ocj.gif|left|200px]]
[[Image:2ocj.gif|left|200px]]
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{{Structure
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|PDB= 2ocj |SIZE=350|CAPTION= <scene name='initialview01'>2ocj</scene>, resolution 2.050&Aring;
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The line below this paragraph, containing "STRUCTURE_2ocj", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_2ocj| PDB=2ocj | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ocj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ocj OCA], [http://www.ebi.ac.uk/pdbsum/2ocj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ocj RCSB]</span>
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'''Human p53 core domain in the absence of DNA'''
'''Human p53 core domain in the absence of DNA'''
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[[Category: Rosengarth, A.]]
[[Category: Rosengarth, A.]]
[[Category: Wang, Y.]]
[[Category: Wang, Y.]]
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[[Category: cancer]]
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[[Category: Cancer]]
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[[Category: p53]]
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[[Category: P53]]
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[[Category: tetramer]]
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[[Category: Tetramer]]
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[[Category: tumor suppressor]]
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[[Category: Tumor suppressor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:37:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:15:56 2008''
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Revision as of 07:37, 4 May 2008

Image:2ocj.gif

Template:STRUCTURE 2ocj

Human p53 core domain in the absence of DNA


Overview

The tumor suppressor protein p53 plays a key role in cell-cycle regulation by triggering DNA repair, cell-cycle arrest and apoptosis when the appropriate signal is received. p53 has the classic architecture of a transcription factor, with an amino-terminal transactivation domain, a core DNA-binding domain and carboxy-terminal tetramerization and regulatory domains. The crystal structure of the p53 core domain, which includes the amino acids from residue 96 to residue 289, has been determined in the absence of DNA to a resolution of 2.05 A. Crystals grew in a new monoclinic space group (P2(1)), with unit-cell parameters a = 68.91, b = 69.36, c = 84.18 A, beta = 90.11 degrees . The structure was solved by molecular replacement and has been refined to a final R factor of 20.9% (R(free) = 24.6%). The final model contains four molecules in the asymmetric unit with four zinc ions and 389 water molecules. The non-crystallographic tetramers display different protein contacts from those in other p53 crystals, giving rise to the question of how p53 arranges as a tetramer when it binds its target DNA.

About this Structure

2OCJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the human p53 core domain in the absence of DNA., Wang Y, Rosengarth A, Luecke H, Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):276-81. Epub 2007, Feb 21. PMID:17327663 Page seeded by OCA on Sun May 4 10:37:06 2008

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