2od1

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[[Image:2od1.jpg|left|200px]]
[[Image:2od1.jpg|left|200px]]
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{{Structure
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|PDB= 2od1 |SIZE=350|CAPTION= <scene name='initialview01'>2od1</scene>
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The line below this paragraph, containing "STRUCTURE_2od1", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= AML1-ETO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2od1| PDB=2od1 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2od1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2od1 OCA], [http://www.ebi.ac.uk/pdbsum/2od1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2od1 RCSB]</span>
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'''Solution structure of the MYND domain from human AML1-ETO'''
'''Solution structure of the MYND domain from human AML1-ETO'''
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[[Category: Roudaia, L.]]
[[Category: Roudaia, L.]]
[[Category: Speck, N A.]]
[[Category: Speck, N A.]]
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[[Category: cross-braced topology]]
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[[Category: Cross-braced topology]]
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[[Category: zinc finger]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:38:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:16:01 2008''
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Revision as of 07:38, 4 May 2008

Image:2od1.jpg

Template:STRUCTURE 2od1

Solution structure of the MYND domain from human AML1-ETO


Overview

AML1/ETO results from the t(8;21) associated with 12%-15% of acute myeloid leukemia. The AML1/ETO MYND domain mediates interactions with the corepressors SMRT and N-CoR and contributes to AML1/ETO's ability to repress proliferation and differentiation of primary bone marrow cells as well as to enhance their self renewal in vitro. We solved the solution structure of the MYND domain and show it to be structurally homologous to the PHD and RING finger families of proteins. We also determined the solution structure of an MYND-SMRT peptide complex. We demonstrated that a single amino acid substitution that disrupts the interaction between the MYND domain and the SMRT peptide attenuated AML1/ETO's effects on proliferation, differentiation, and gene expression.

About this Structure

2OD1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity., Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH, Cancer Cell. 2007 Jun;11(6):483-97. PMID:17560331 Page seeded by OCA on Sun May 4 10:38:46 2008

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