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2kom
From Proteopedia
(Difference between revisions)
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==Solution structure of humar Par-3b PDZ2 (residues 451-549)== | ==Solution structure of humar Par-3b PDZ2 (residues 451-549)== | ||
| - | <StructureSection load='2kom' size='340' side='right' caption='[[2kom]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2kom' size='340' side='right'caption='[[2kom]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kom]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2kom]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOM FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARD3, PAR3, PAR3A ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARD3, PAR3, PAR3A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kom OCA], [https://pdbe.org/2kom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kom RCSB], [https://www.ebi.ac.uk/pdbsum/2kom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kom ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/PARD3_HUMAN PARD3_HUMAN]] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.<ref>PMID:19812038</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Peterson, F C]] | [[Category: Peterson, F C]] | ||
Revision as of 07:29, 14 April 2021
Solution structure of humar Par-3b PDZ2 (residues 451-549)
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Categories: Human | Large Structures | Structural genomic | Peterson, F C | Tyler, R C | Volkman, B F | Alternative splicing | Cell cycle | Cell division | Cell junction | Cell membrane | Cesg | Coiled coil | Cytoplasm | Cytoskeleton | Membrane | Par-3b | Pdz domain | Phosphoprotein | Polymorphism | PSI, Protein structure initiative | Signaling protein | Tight junction
