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2kno
From Proteopedia
(Difference between revisions)
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==NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1)== | ==NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1)== | ||
| - | <StructureSection load='2kno' size='340' side='right' caption='[[2kno]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2kno' size='340' side='right'caption='[[2kno]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kno]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2kno]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KNO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KNO FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA1075, TENC1, tensin like C1 domain containing phosphatase, TNS2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIAA1075, TENC1, tensin like C1 domain containing phosphatase, TNS2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kno FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kno OCA], [https://pdbe.org/2kno PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kno RCSB], [https://www.ebi.ac.uk/pdbsum/2kno PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kno ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TENC1_HUMAN TENC1_HUMAN]] Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.<ref>PMID:15817639</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Chen, L]] | [[Category: Chen, L]] | ||
[[Category: Feng, R]] | [[Category: Feng, R]] | ||
Revision as of 07:29, 14 April 2021
NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1)
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Categories: Human | Large Structures | Chen, L | Feng, R | Liu, C | Zhu, G | Cell junction | Cell membrane | Hydrolase | Membrane | Metal-binding | Phorbol-ester binding | Phosphoprotein | Protein phosphatase | Sh2 domain | Solution structure | Tenc1 | Tensin2 | Zinc-finger
