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2l34
From Proteopedia
(Difference between revisions)
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==Structure of the DAP12 transmembrane homodimer== | ==Structure of the DAP12 transmembrane homodimer== | ||
| - | <StructureSection load='2l34' size='340' side='right' caption='[[2l34]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | + | <StructureSection load='2l34' size='340' side='right'caption='[[2l34]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l34]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2l34]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L34 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L34 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2hac|2hac]], [[2k4f|2k4f]], [[2l35|2l35]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2hac|2hac]], [[2k4f|2k4f]], [[2l35|2l35]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TYROBP, DAP12, KARAP ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TYROBP, DAP12, KARAP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l34 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l34 OCA], [https://pdbe.org/2l34 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l34 RCSB], [https://www.ebi.ac.uk/pdbsum/2l34 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l34 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN]] Nasu-Hakola disease. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN]] Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Call, M E]] | [[Category: Call, M E]] | ||
[[Category: Chou, J J]] | [[Category: Chou, J J]] | ||
Revision as of 07:35, 14 April 2021
Structure of the DAP12 transmembrane homodimer
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