2kw3
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Heterotrimeric interaction between RFX5 and RFXAP== | ==Heterotrimeric interaction between RFX5 and RFXAP== | ||
| - | <StructureSection load='2kw3' size='340' side='right' caption='[[2kw3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2kw3' size='340' side='right'caption='[[2kw3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kw3]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2kw3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KW3 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RFX5 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RFX5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), RFXAP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kw3 OCA], [https://pdbe.org/2kw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2kw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kw3 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RFX5_HUMAN RFX5_HUMAN]] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry. [[https://www.uniprot.org/uniprot/RFXAP_HUMAN RFXAP_HUMAN]] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/RFX5_HUMAN RFX5_HUMAN]] Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. [[https://www.uniprot.org/uniprot/RFXAP_HUMAN RFXAP_HUMAN]] Part of the RFX complex that binds to the X-box of MHC II promoters. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 24: | Line 24: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Boss, J M]] | [[Category: Boss, J M]] | ||
[[Category: Briggs, L L]] | [[Category: Briggs, L L]] | ||
Revision as of 07:32, 14 April 2021
Heterotrimeric interaction between RFX5 and RFXAP
| |||||||||||
Categories: Human | Large Structures | Boss, J M | Briggs, L L | Garvie, C W | Laird, K M | Summers, M F | Dna binding protein | Enhanceosome | Mhcii | Rfx5 | Rfxap
